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This Concept Map, created with IHMC CmapTools, has information related to: Week 15, Rituximab disease modifying anti-rheumatic drug therapy for... Rheumatoid Arthritis, Methotrexate First line treatment! Rheumatoid Arthritis, IgM IgM is an autoantibody against Fc fragment on IgG Fc Fragment, Pannus pannus is a mass oc edematous synovium containing macrophages and plasma cells Macrophages, Fc Fragment Contains heavy & light chain isoptypes to form: Immune Complexes, Osteoarthritis Inflammation of synovium, OA symptom Synovium, Infliximab disease modifying anti-rheumatic drug therapy for... Rheumatoid Arthritis, Rheumatoid Arthritis Symptoms of RA include: Swan neck deformity, Collagen Type collagen is a precursor of connective tissues like bone Bone erosion, Pain in MCP joints RA presents with symmetric joint pain in: hands (except DIP), wrists, hips, knees, feet, ankles, elbows, shoulders, and spine Symmetric polyarthritis, Methotrexate disease modifying anti-rheumatic drug therapy for... Rheumatoid Arthritis, TNF-alpha is a TNFa inhibitor biologic DMARD Biologic TNF DMARD, Rheumatoid Arthritis RF is sensitive for autoimmune diseases Rheumatoid factor, Antibody testing specific antibody positive in patients with RA Anti-CCP, IgM First Ab secreted against foreign Ag Infectious arthritis, Methotrexate contraindicated in pregnancy! teratogenic & fetotoxic HCG, Osteoclasts Main cell type responsible for breaking down bone Bone erosion, CBC Used to assess overall health & detect a variety of disorders, including infections and RA. Rheumatoid Arthritis, Pannus pannus is a mass oc edematous synovium containing macrophages and plasma cells B-cells, Immune Complexes Type III Hypersensitivity reaction IgM