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This Concept Map, created with IHMC CmapTools, has information related to: Week 13 - Eric and Harley, Bacterial meningitis increase CSF protein, Focal focal symptoms Petechia, Focal focal symptoms Headache, Meningeal inflammation Pain felt in extension of knee Kernig's Sign, Kernig's Sign Special test for meningeal inflammation Brudzinkski's sign, Fever Both defenses of innate immune response Complement, Sialic acid Both contribute to the survival of bacterial meningitis Nitric Oxide, Shingrix recombinant vacinne for adults 50 and older, used in place of Zostavax VZV, Bacterial meningitis little change Lymphocytes, HSV Both can remain latent in DRG VZV, Focal focal symptoms Fever, Complement Asplenic pts are more susceptible to encapsulated bacterial infection due to no complement MAC N. meningitidis, Nitric Oxide nitric oxide procuded in excess in bacterial meningitis, nitric oxide inhibitors can be use as a treatment Bacterial meningitis, Fever Symptoms of Meningeal inflammation, Lumbar puncture Sample taken will not show positive on culture Aseptic meningitis, Acyclovir Will not be beneficial in pathogens that do not show on gram stain Gram stain, Empirical Antimicrobial Therapy First line treatment Bacterial meningitis, Altered Mental Status Symptom of Meningeal inflammation, Gram stain gram negative N. meningitidis, PMNs There is no/slight change on labs Viral meningitis