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This Concept Map, created with IHMC CmapTools, has information related to: Hershel_Greene_C3_Final, Vitamin K deficiency causes increased clotting time in both intrinsic and extrinsic pathways Prothrombin time (PT), Pulmonary embolism one complication of HIT is the formation of thrombi, which can dislodge and be transported to a vessel in the lung Heparin-induced Thrombocytopenia (HIT), Chest X-ray (CXR) CXR of a patient w/ a pulmonary embolism may reveal a blockage of one of the lung vessels Pulmonary embolism, Fibrin tPA is synthesized by the endothelium and is most active when bound to fibrin, this makes tPA a useful therapeutic agent since its fibrinolytic activity is confined to sites of recent thrombosis Thrombosis, Hemoglobin (Hb) HIT is due to platelet dysfunction, and thus Hct and Hb may appear unchanged Heparin-induced Thrombocytopenia (HIT), Antithrombin (AT) can be activated via conformation changes in the protein that enhances Factor Xa binding by Heparin, PF4 implicated in HIT due to complexes formed with heparin that are targeted by IgG Heparin-induced Thrombocytopenia (HIT), Hematocrit (Hct) HIT is due to platelet dysfunction, and thus Hct and Hb may appear unchanged Heparin-induced Thrombocytopenia (HIT), Platelets The Fc receptor on platelets bind to the constant region of immunoglobulin Fc Receptor, von Willebrand factor A defeicency in VWF is a common inherited clotting disorder Clotting Disorders, Hershel Greene 65 y.o. male had a negative D-dimer test, which does not indicate recent intravascular coagulation D-dimer test, Extrinsic pathway activated via tissue damage that causes the blood to leave the vasculature by releasing tissue factor III which goes on to activate factor VII Factor VII, 4T score the 4T score can rule out HIT from other causes of thrombocytopenia Thrombocytopenia, Thrombosis defined as blood clotting the vessels of the body specifically in the deep veins of the body. Can be treaed with anti-coagulants such as heparin and Warfarin, Thrombin can pass to the main pulmonary artery, straddle bifurcation, or pass into smaller branching arteries, causing occlusion Pulmonary embolism, Plasmin degrades fibrin clots, can be inhibited by alpha2-plasmin. Degradation creates byproducts which can be seen with D-dimer test, Fatigue low Hb causes decreased oxygen-carrying capacity of RBCs and decreased iron in blood, contributing to fatigue Hemoglobin (Hb), IgG in HIT, IgG forms a complex w/ PF4 and heparin, and binds to the Fc receptor of platelets, causing thrombosis Fc Receptor, Vitamin K deficiency causes increased clotting time in both intrinsic and extrinsic pathways Partial thromboplastin time (PTT), Vascular injury exposes subendothelium which releases factors to start coagulation Tissue Factor