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This Concept Map, created with IHMC CmapTools, has information related to: Hershel_Greene_C3_1, Thrombosis Plasminogen deficiency may reduce the ability to degrade thrombosis, resulting in increased severity of the thrombosis Plasminogen, Vascular injury exposes subendothelium which releases factors to start coagulation Tissue Factor, Warfarin decreases levels of reduced Vitamin K, which results in the reduced activation of various clotting factors, including Factor VII Vitamin K, Vitamin K deficiency causes increased clotting time in both intrinsic and extrinsic pathways Partial thromboplastin time (PTT), Fibrinogen one of the final steps of the clotting cascade is when Fibrinogen is converted to Fibrin via Factor I (Thrombin) Fibrin, Intrinsic pathway the intrinsic pathway is activated by damage from within a blood vessel Vascular injury, Prothrombin time (PT) coagulation requires Tissue Factor, phospholipids, and citrated plasma. Clotting initiation occurs by adding exogenous calcium and time to clot is recorded. This method is used to monitor Warfarin therapy Warfarin, Thrombosis defined as blood clotting the vessels of the body specifically in the deep veins of the body. Can be treaed with anti-coagulants such as heparin and Warfarin, Hematocrit (Hct) HIT is due to platelet dysfunction, and thus Hct and Hb may appear unchanged Heparin-induced Thrombocytopenia (HIT), Hershel Greene 65 y.o. male had a negative D-dimer test, which does not indicate recent intravascular coagulation D-dimer test, von Willebrand factor is used in platelet adhesion by acting as a bridge between the platelet GpIb receptors and subendothelial collagen Platelets, Plasmin degrades fibrin clots, can be inhibited by alpha2-plasmin. Degradation creates byproducts which can be seen with D-dimer test, Hematocrit (Hct) a low Hct level can produce symptoms of anemia, including fatigue, due to decreased Hemoglobin Fatigue, Plasminogen converted to plasmin via tissue plasminogen activator (tPA) Plasmin, PF4 ELISA a serology assay used to measure the likelihood of Type II HIT Heparin-induced Thrombocytopenia (HIT), PF4 PF4 ELISA detects the antibodies attached to the complex of PF4 and heparin in HIT PF4 ELISA, Tissue Factor Tissue Factor is involved in coagulation and a part of the extrinsic pathway Extrinsic pathway, Hershel Greene 65 y.o. male OSE shows T3-5NSlRr; TART Changes: boggy +red reflex, warmth, and stiffness. These changes can be indicative of an acute pulmonary embolism Pulmonary embolism, Aspirin can be used at a dose less than 300 mg to prevent Thrombosis, Endothelium damage leads to endothelin release which causes vasoconstriction leading to the next steps of platelet adhesion Platelets