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This Concept Map, created with IHMC CmapTools, has information related to: Case 6 - Robert Dillon, Type IV Hypersensitivity SJS is an example of a delayed Type IV HSR. Stevens-Johnson Syndrome (SJS), Type III Hypersensitivity Type 3 hypersensitivity is a type of Ab-mediated immune response Antibody-Mediated, MHC there are two classes of MHC molecules that are important for facilitation of cell-mediated immune response Cell-Mediated, Innate Immune System Both complement and bradykinin are mediators of the innate immune system Complement, T-Helper Cells T helper Cells express CD4+ TCR T-Cell Receptor (TCR), Cyclosporine Cyclosporine is used to prevent organ transplant, which is a Type IV HSN Type IV Hypersensitivity, IgM IgM and IgG bound to antigens activates the classical pathway of complement Complement, Purified Protein Derivative (PPD) delatyed type IV hypersensitivity reactions are cell medated Type IV Hypersensitivity, Anaphylaxis An anaphylactic reaction is an example of a Type 1 HSR. IgE, Type II Hypersensitivity For type 2 hypersensitivity, IgM and IgG directly bind to antigens IgM, Cell-Mediated involves CD4+ T-helper cells which help further the immune response and stimulate Ig production T-Helper Cells, Type II Hypersensitivity MG is a type II HSR involving autoantibodies binding acetylcholine receptors on skeletal muscle cells Myasthenia Gravis, Bradykinin Bradykinin mediates inflammation by increasing venular dilation and vascular permeability Inflammation, T-cytotoxic Cells expresses CD8+ TCR T-Cell Receptor (TCR), Sulfonamides Sulfonamides can cause Type III HSN reactions Type III Hypersensitivity, Innate Immune System Both complement and bradykinin are mediators of the innate immune system Bradykinin, Antibody-Mediated involves immunoglobulins such as IgE, IgM, IgG, and IgA IgG, IgG IgM and IgG bound to antigens activates the classical pathway of complement Complement, Robert Dillon is a 28-year-old Hispanic male who presents to the clinic with a blistering, painful rash CC: "I have a rash that is spreading everywhere" patient's ROS, PE, and OMT findings include ROS, PE, and OMT findings: - rash on face, trunk, back, and genitals; blisters observed on face and trunk - TART changes and SDs noted at OA, cervical spine, thoracic spine, ribs, lumbar spine, pelvis, and sacrum + fever, chills, sweats + sore throat before rash + generalized mm. pain, Laboratory Studies: - skin biopsy - erythrocyte sedimentation rate - c-reactive protein - complete blood count with differential - comprehensive metabolic panel - direct immunofluorescence - EKG - bacterial and fungal cultures - chest x-ray a HPI that indicates risk of snake venom may indicate use of Antivenom