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This Concept Map, created with IHMC CmapTools, has information related to: Perio 1st concept map, Increased internal pressure leading to engorged and congested BV, Clinically Healthy Gingiva associated bacteria include Streptococcus sanguis, no gingival sulcus due to zero inflammation, Periodontitis under the microscope, shows domination of plasma cells, Predominance of plasma cells (10-30% of CT vol) causing Increased internal pressure, proper oral hygiene includes proper toothbrushing, release of signal other cells to produce Receptor Activator of Nuclear factor Kapps-B Ligand (RANK-L) which then bind to preosteoclast, Early Lesion/ Early Gingivitis under the microscope epithelial rete pegs, 4. Autoaggregation increases adhering bacteria of the same species, Established Lesion/ Established Gingivitis under the microscope pocket epithelium, gingival recession wherein the gingival level will follow the bone, Clinically Healthy Gingiva associated bacteria include Streptococcus oralis, domination of plasma cells indicates chronic inflammation, release large quantities of destructive enzymes (e.g. MMPs) as they migrate through the tissues results in breakdown of structural components of the periodontium, Local Factors (IL-1, PGE2, Tissue Necrosis Factor (TNF)) function induce maturation of preosteoclasts to form osteoclasts and bone resorption, Clinically Healthy Gingiva associated bacteria include Capnocytophaga gracilis, extension of the inflammatory infiltrate in the direction apically, Chemical Mediators produced by complement cascade and kinin system, proper oral hygiene includes rinsing with anti-plaque mouthwash, bind to preosteoclast leads to maturation to osteoclast