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This Concept Map, created with IHMC CmapTools, has information related to: Immuno, low level CD4+ leads to high bacterial load, HIV infectred cell attaches to CD4+Tcell via gp120 leads to destroys CD4Tcell (90%), granuloma (caseous necrosis) seen CXR, latent TB leads PPD +, TH1 CD4+ cell secrete IFN-g, destroys CD4Tcell (90%) leads to low level CD4+, fuses phagosome with lysosome presents via MHCII TH1 CD4+ cell, TH1 CD4+ cell secrete TNF-a, uptake by alveolar macrophages ???? fuses phagosome with lysosome, TH1 CD4+ cell secrete IL-12, air on coughing enters lungs, destroys CD4Tcell (90%) leads to low level CD4+, TH1 CD4+ cell secrete IL-18, IFN-g ???? ????, alveoli recognize by resident dendritic & macrophages, fuses phagosome with lysosome presents via MHCII TH1 CD4+ cell, granuloma (caseous necrosis) seen CXR