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Deze Concept Map heeft informatie gerelateerd aan: Cmap 1, VEGF bindt aan VEGH1 receptor, Kinase domain receptor binds to from L-24 region Heterodimer SMAD-2/SMAD-3, RB/E2F complex Phosphorylated by D-cdk4, Target gene translated into proteins SMAD-6, SMAD-7 Binds to and inhibits TGFβ ligand binding TGFβ-RII (Receptor type II), Target gene translated into proteins SMAD-7, TGFβ-RII (Receptor type II) Activates the Serine residues on TGFβ-RI (Receptor Type I), Hypoxie stimuleert HIF1, SARA Anchors to Heterodimer SMAD-2/SMAD-3, Proteosome Undenatured bi-product MDM2, TGFβ-RI (Receptor Type I) Activates and Phosphorylates its Kinase domain receptor, Retinoblastoma protein (RB) bind and form the RB/E2F complex, Kinase domain receptor binds to from L-24 region SARA, Activated SMAD-2/SMAD-3 Heterodimer Binds to and forms SMAD-4, Retinoblastoma protein (RB) bind and form the E2F protein, p53 protein binds to and activates p21 protein, p21 protein Inhibits the activation of G1/S-Cdk, RB/E2F complex Phosphorylated by ????, HIF1 bindt aan VEGF, Heterotrimer SMAD complex binds to the promoter region of Target gene