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This Concept Map, created with IHMC CmapTools, has information related to: Module 4 - Patterning the Chick Limb, proximal structures which are formed before differentiated and form into distal structures, AER removal of reults in early removal: only humerus, Digits grow posterior to anterior (4, then 3, then 2) form Digit 2: low SHH conenctration, a zone of proliferation thought to be FGFs as the molecule responsible, Dinos had thumbs but where they opposable?, Progress zone cells that have gone through numerous divisons become differentiated and form into distal structures, AER comprised of ectodermal cells, duration dependant resulting in Digits grow posterior to anterior (4, then 3, then 2), zone of polarity which is in distal posterior area of the wing bud, Shh defines the zone of polarity, duration dependant rather than concentration dependent, How is the proximal/distal axis patterned? determined by AER, fgf-10 in mesenchyme upregulates FGF-8 from AER, Digits grow posterior to anterior (4, then 3, then 2) form Digit 3: brief SHH expression, high SHH concenctration, Digits grow posterior to anterior (4, then 3, then 2) form Digit 4: Moderate SHH expression, cartilage formation in mesenchymal cells forming Progress zone, Progress zone which is a zone of proliferation, AER inhibit cartilage formation in mesenchymal cells, Shh which is duration dependant, fgf-8 signal which induces fgf-10 in mesenchyme