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This Concept Map, created with IHMC CmapTools, has information related to: Colorectal Cancer efficacy endpoints v10, Existing lesion identified by Anatomical region, Yes differentited by Rectal Ca, Mutation subtype specified by Standard nomenclature, Existing lesion have response options - Absent - Stable - Unequivocal Progression - Absent/Stable - Any, Non surgical Liver-directed therapy instantiated by - Yes - No, Colorectal Cancer Stage has Name of the staging criteria, Quantitative assessment represented by Sum of the products of the two largest perpendicular diameters (SPD) per lesion assessed to assign irRECIST overall response (e.g. lesion 1 is 4x3=12, lesion 2 is 4x4=16, Sum of 12 and 16 is 28), -Complete Response (CR) -Partial Response (PR) -Not all evaluated -Stable disease (SD) -Progressive disease (PD) summarized into OVERALL RESPONSE, Colo-rectal Cancer Stage instantiated by - 0 - I - IIA - IIB - IIC - IIIA - IIIB - IIIC - IVA - IVB, Risk Features include obstruction, Concepts are denoted by solid round-edged rectangle, Prior Therapy include Non surgical Liver-directed therapy, Regional Lymph Nodes (N) instantiated by NX N0 N1 N1c N2a N2b N2, Curative Intent include Post-neoadjuvant therapy stage by imaging, poorly differentiated histology instantiated by - Yes - No, Risk Features include perforation, Recurrence or Progression measured at Date of Recurrence or Progression, Sum of longest diameters (SLD) have response options -Complete Response (CR) -Partial Response (PR) -Not all evaluated -Stable disease (SD) -Progressive disease (PD), Pathologic Stage provides evidence for pCR, Disease characteristics include Immunohistochemistry