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This Concept Map, created with IHMC CmapTools, has information related to: Mets Brain Tumors efficacy endpoints v8, Time To Salvage Therapy In the Brain measured by Date of Salvage Therapy, Target lesion evaluated by Quantitative assessment, Yes instantiated by - Symptoms - Neurocognitive Outcomes - HRQoL - Functional Status, Progression free survival (PFS) has subtypes Non-CNS Lesion, Sum of the product of all lesions includes Total area of each leasion, Number of brain metastases instantiated by - single - multiple, Non-target lesion evaluated by Qualitative Assessment, Status of primary lesion instantiated by - controlled - uncontrolled, Regional includes Convection enhanced delivery, CNS (Brain) Lesion classified as NON-ENHANCING, METASTATIC BRAIN TUMORS EFFICACY ENDPOINTS include Overall Survival (OS), Objective Response Rate (ORR) derived from Tumor Response, Tumor Volume has attribute cm^3, Non-CNS Lesion assesses by RECIST 1.1, Regional includes Surgical Resection, Repeated concepts/instances throughout the CMAP are denoted by dotted outline, Tumor Response is assessed with MRI, Therapeutic Efficacy Endpoint is intersection of Therapeutic Intervention, Disease characteristics include Brain Tumor/Metastases Origin, ENHANCING classified as Non-measurable lesions