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This Concept Map, created with IHMC CmapTools, has information related to: Miller Case, metaphysis or endochondral plate causing abreviated growth in one leg, bone marrow transplant inserts normal osteoblasts, Management/Treatment of Infant OI . 1. Care with handling 2. Fracture management 3. Healthy diet 4. Safe exercise 5. Physical therapy after fracture, bone marrow transplant type of cell therapy, Pamidronate (bisphosphonates) . osteoblast lineage cells, patient Nancy Miller has osteogenesis imperfecta, COL1A1 gene for production of Type I, osteomyelitis occuring in metaphysis or endochondral plate, ruffled border secretes protons/enzymes, gene supplemental approaches involving ex-vivo gene delivery to bone, Management/Treatment of Infant OI use of cell therapy, Pamidronate (bisphosphonates) inhibits fasenyl pyrophosphate synthase, bone inorganic porti hydroxyapatite, gene supplemental approaches involving antisense gene therapy, RANKL inhibit differentiation of osteoclasts, look for bowing of long bones . Coud not provide diagnosis, cytoskeleton ???? ruffled border, protons/enzymes breakdown bone, fibroblasts collected with skin biopsy, osteoblast lineage cells decreased production of RANKL