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This Concept Map, created with IHMC CmapTools, has information related to: Primary Brain Tumors efficacy endpoints v1, Sum of longest diameters (SLD) has component LD (axial plane) for target lesion, PRIMARY BRAIN TUMORS EFFICACY ENDPOINTS include Overall Survival (OS), Neurologic Signs and Sympotms have attributes Burden, -Complete Response (CR) -Non-CR/non-PD -Not all evaluated -Non-PD -PD summarized into OVERALL RESPONSE, Measurable lesions has subtype Non-target lesion, Histology provides evidence for Cellular Classification, % Staining provides evidence for Intensity score, PRIMARY BRAIN TUMORS EFFICACY ENDPOINTS include Progression free survival (PFS), Lesion has type Existing lesion, Progression free survival (PFS) is measured by Tumor Choline Concentration, Tumor Response is assessed with - MRI - CT - FLAIR MRI, Prior Therapy include Systemic, Progression free survival (PFS) is measured by C-MET PET F-FET PET, newly added concepts are denoted by green color outlines, Immunohistochemistry has outcome - Negative - Positive - Other, WHO grades: I II III IV ???? Mitotic Activity, Neurologic Signs and Sympotms assessed as - Cognition - HRQoL - Seizure - Leukoencephalopathy - Infection, Overall Survival (OS) measured between Date of Randomization, Sum of longest diameters (SLD) has component Short axis for target lymph nodes, New lesion identified by Anatomical region