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This Concept Map, created with IHMC CmapTools, has information related to: Endocarditis, intracellular uptake of bacteria for Coxiella burnettii, bloodculture often negative for Bartonella sp., inflamed endothelium starts with platelet-fibrin aggregates (NBTE), S. aureus note mostly S. aureus, native colonization of injured endothelium, nursing homes dialysis units causative agents mostly S. aureus, bloodculture delayed with HACEK, nursing homes dialysis units causative agents Enterococcus, infective Endocarditis nature of valve native, adherence of bacteria potentially followed by intracellular uptake of bacteria, CoNS, e.g. Staph epidermidis note CoNS, e.g. Staph epidermidis, CoNS, e.g. Staph epidermidis mostly due to bacterial biofilms, intracellular uptake of bacteria refractory to treatment with antibiotics, bloodculture generally positive for S. aureus, infective Endocarditis special cases IV Drug users, prosthetic timing late onset, early onset most commonly caused by CoNS, e.g. Staph epidermidis, non-nosocomial mostly associated with nursing homes dialysis units, prosthetic IE often caused by bacterial biofilms, bacterial biofilms refractory to treatment with antibiotics