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This Concept Map, created with IHMC CmapTools, has information related to: innate immunity2, phagocytes: neutrophils & monocytes/ macrophages when activated, macrophages produce phagocyte oxidase iNOS fibroblast growth factors... cytokines (TNF, IL-12) incrd MHC molecules, costimulators, innate immune system responds to EC bacteria and fungi w/ complement system, macrophage-activating cytokines (e.g. IL-12) activates macrophages phagocytes: neutrophils & monocytes/ macrophages, innate immune system has the following components natural killer cells, innate immune system has the following components other plasma proteins of inn imm, physical and chemical barrier to infection at skin, GI, resp tracts e.g. defensin (ancient, naturally occuring peptide antibiotic), cytokine of innate imm pg 39 Abbas can act autocrine or paracrine, innate immune system has the following components epithelial barriers, innate immune system has the following components cytokine of innate imm pg 39 Abbas, co-stimulator expression and cytokine production results in cell-mediated imm T-cell prolif. and differentiation, natural killer cells produces interferon-gamma INF-gamma, receptors for: mannose N-formyl methionine-containng petides Mac-1 (an integrin) scavenger receptros Toll like antibodies and complement others yet to be ID'd recognize microbes phagocytosis, cytokine of innate imm pg 39 Abbas activate macrophages (IFN-gamma), after infection called acute phase response, limited cellular receptors have limited diversity, immutable, phagocytes: neutrophils & monocytes/ macrophages have receptors for: mannose N-formyl methionine-containng petides Mac-1 (an integrin) scavenger receptros Toll like antibodies and complement others yet to be ID'd, class I MHC- self peptide complex expression if inhib receptor not engaged, eliminates virus-infected cells, other plasma proteins of inn imm levels increase after infection, innate immune system recognizes and respond to almost all microbes by limited cellular receptors, innate immune system has the following components limited cellular receptors