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This Concept Map, created with IHMC CmapTools, has information related to: Bacteriology 2 Bacterial Pathogenesis, there are defenses in each of the 5 possible routes of infection: intact skin respiratory tract GI tract urinary tract gential tract only sterile env is urinary tract, endotoxins are structural part of bacteria, bacteria secretes exotoxins, biofilm char matrix protects bacteria from host defenses, limit chemotaxis of leukocytes by degrading C5a, the chemical attractant used by Streptococcus pyogenes, produce coagulase, promotes fibrous barrier used by Staphylococcus aureus, Discuss mechanisms in evasion of host defenses by bacteria include limit chemotaxis of leukocytes by degrading C5a, the chemical attractant, exotoxins are polypeptides, Discuss mechanisms in evasion of host defenses by bacteria include long O antigen of LPS prevents complement from accessing membrance -> inhibiting complement cascade, Discuss mechanisms in evasion of host defenses by bacteria include produce protease to degrade IgA, exotoxins are antigenic, makes protein A, an IgG-binding protein used by Staphylococcus aureus, varying structure of surface antigens to evade AB response used by Neisseria gonorrhoeae, Discuss mechanisms in evasion of host defenses by bacteria include varying structure of surface antigens to evade AB response, makes protein A, an IgG-binding protein to prevent opsonization - marking a pathogen for phagocytosis w/ an antibody (e.g. IgG, C3b; Fc-R & C3b-R on phagocytes), Discuss mechanisms in evasion of host defenses by bacteria include develop granuloma to survive in host, biofilm char matrix facilitates colonization of host tissues, Discuss mechanisms in evasion of host defenses by bacteria include produce coagulase, promotes fibrous barrier, superantigen mechanism non-specific T-cell activation, Discuss mechanisms in evasion of host defenses by bacteria include makes protein A, an IgG-binding protein