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Deze Concept Map heeft informatie gerelateerd aan: Allergic Contact Dermatitis Cmap, LC Secrete NO, Circulating IgM Leads to Complement activation, MHC class 2 No CD80/CD86 CD4+ T cell anergy, Keratinocytes (KC) Production of supressive cytokines Il-10 and Il-16, Expression of MHC class I Induces IFN-γ, Haptens applied to the skin Release of Uncharacterized Endogenous Glycolipids, Proliferation of T cells into a Th1 phenotype Triggers Clinical manifestations of Allergic Contact Dermatitis, CD205 Leads to Activation natural regulatory T cells (nTreg), Antigen-specific CD8+ T cells Other inflammatory cytokines and cell-mediated cytotoxicity Clinical manifestations of Allergic Contact Dermatitis, IL-12 Leading to Proliferation of T cells into a Th1 phenotype, IL-10 Inhibits effector T cells Antigen-specific CD8+ T cells, Haptens applied to the skin Release of Uncharacterized Endogenous Glycolipids, Antigen-specific CD8+ T cells Cytokine release IFN-γ, Complement activation Leads to release of inflammatory and chemotactic factors from Mast cells, Haptens applied to the skin Activate iNOS on LC, CD11a Bind to ICAM-1, IFN-γ producing T cells (Th1) Induces Keratinocytes (KC), Proliferation of T cells into a Th1 phenotype Triggers Clinical manifestations of Allergic Contact Dermatitis, cellular infiltration Aspect of Clinical manifestations of Allergic Contact Dermatitis, Hapten-Protein Complexes Engulfed by Antigen Presenting Cells (such as Langerhans Cells)