Critically analyze the etiology and pathophysiological alterations associated with common healthcare conditions. Examine relevant theories and evidence-based research as a basis for explaining the pathophysiological changes and rationales for therapeutic interventions. Discuss the issues and considerations associated with pathophysiological changes related to culturally diverse populations and patients with special needs. Utilize critical thinking in the application of pathophysiological principles to case situations as a basis for advanced nursing practice based on holism and caring. Utilize critical thinking to synthesize current research findings with evidence-based guidelines to enhance nursing care delivery in the management of selected diseases. Altered Cellular and Tissue Integrity. Genetics. Innate Immunity. Adaptive Immunity. Alterations in Immunity and Inflammation. Infection. Biology and Treatment of Cancer. Tumor Invasion and Metastasis. Disorders of Neurological Function. Alterations in Musculoskeletal System. Alterations of Hormonal Function. Alteration of Reproductive System. Alterations of Erythrocytes. Leukocytes, Lymphoid and Hematopoietic Tissue. Alterations in Cardiac Function. Alterations in Pulmonary Function. Alterations in Renal and Urinary Function. Alterations in Digestive Function. MODS, Burns, Shock.