Critically analyze advanced concepts of pharmacotherapeutics and pharmacokinetics as they apply to nursing practice. Examine relevant theories and evidence-based research as a basis for explaining the rationale for pharmacotherapeutics. Discuss the issues and considerations associated with pharmacotherapeutics related to culturally diverse and special needs populations. Utilize critical thinking in the application of pharmacotherapeutics principles to case situations as a basis for advanced nursing practice based in caring and holism. Foundations for Drug Therapy in Nursing. Core Drug Knowledge, Core Patient Variables. Peripheral and Central Nervous System Drugs. Analgesic and Anti-inflammatory Drugs. Cardiovascular and Renal System Drugs. Hematopoietic and Immune System Drugs. Antimicrobial Drugs. Respiratory System Drugs. Gastrointestinal System Drugs. Endocrine System Drugs. Integumentary System and Musculoskeletal System Drugs.