Identify the role of the advanced practice nurse related to evidence-based practice. Identify significant nursing problems related to education and leadership and use evidence-based research to solve the problems. Evaluate outcomes of nursing interventions using new knowledge obtained from nursing research. Utilize information systems for the storage, retrieval and analysis of data. Critically appraise original research for practice implications in the context of evidence-based practice. Critically appraise clinical practice guidelines from various sources. Assume the role of change agent to facilitate evidence-based practice changes and engage in practice that reflects caring and holism. Participate in the translation of evidence-based summaries and clinical practice guidelines into clinical innovations. Evidence based practice in nursing. Evidence based practice in healthcare. Evidence-based nursing research. Role of advanced practice nursing. Using new knowledge to improve practice. Mechanics of research. Databases. Information systems. Evidence-based nursing research process. Developing a proposal. Critical appraisal of evidence-based guidelines. Systematic reviews of research.