WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Mr. Turtle's Gout, hypoxanthine-guanine phoshoribosyl transferase (HGPRT) produces GMP, Phoshoribosyl Pyrophosphate (PRPP) catalyzed by 9-step process to IMP, PRPP synthetase produces Phoshoribosyl Pyrophosphate (PRPP), hypoxanthine in purine salvage, converted to IMP, GOUT treatments NSAIDs, PRPP synthetase requires Mg++, 43 y/o obese white male with BMI 41.6, hyperuricemia caused by overproduction or underexcretion of uric acid, Chris Turtle is a 43 y/o obese white male, purines converted to hypoxanthine, Chris Turtle Tests performed Synovial fluid: needle shaped crystals, innate immune response release of pro-inflammatory cytokines leads to inflammation of joints (most commonly great toe), Chris Turtle presents with no Hx of trauma, GOUT treatments corticosteroids, HGPRT deficiency known as Lesch-Nyhan Syndrome, loop diuretic act on promotes ion and fluid excretion, hypoxanthine added to Phoshoribosyl Pyrophosphate (PRPP), Chris Turtle presents with severe pain, erythema, and swelling in right great toe pain, unhealthy lifestyle involves reduced activity levels, Labs: high serum uric acid level (8.8 mg/dL) classified as hyperuricemia