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This Concept Map, created with IHMC CmapTools, has information related to: Untitled, ABCA1 DECREASING EFFLUX OF cholesterol, decreased exchange of cholesterol FOR triacylglycerol, cholesterol esters to LIVER, nascent HDL AND THEREFORE half-normal plasma HDL levels, oxidized LDL engulfed by arterial macrophages, inflammation stimulating recruitment of more arterial macrophages, cholesterol RESULTING IN decreased exchange of cholesterol, Heterozygous Patient for mutation on ABCA1 gene, peripheral cell membranes facilitates transfer of cholesterol, ABCA1 RESULTS IN MALFORMATION OF nascent HDL, arterial macrophages TRANSFORM INTO foam cells, cholesterol RESULTING IN intracellular accumulation of cholesterol, lipoprotein lipase to degrade triacylglycerol, Apo C-II transferred to VLDL, other lipophilic compounds RESULTING IN accumulation of lipophilic compounds in peripheral tissues, Apo A-I into endosomes, Homozygous Patient WOULD EXPERIENCE enlarged tonsils, IDL some of which is taken up in liver by Apo E, rapid renal filtration and catabolism of Apo A-I, endocytic vesicles containing cholesterol and Apo A-I released as nascent HDL