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This Concept Map, created with IHMC CmapTools, has information related to: Basal Ganglia, Basal Ganglia: Dopamine modulating "Fine Tuning" Indirect Pathway Sub. nigra, Globus Pallidus (internal) VA/VL complex of thalamus, Sub. Nigra D1 + Caudate/Putamen, Globus Pallidus (internal) VA/VL complex of thalamus, Sub. nigra D2 - Caudate/Putament, VA/VL complex of thalamus Frontal Cortex, VA/VL complex of thalamus Frontal Cortex, Basal Ganglia: Dopamine modulating "Fine Tuning" Direct Pathway: Made up of D1 and D5 Caudate/Putamen, Basal Ganglia: Dopamine modulating "Fine Tuning" Pathology Parkinson's Disease, Subthalamic nucleus Globus Pallidus (internal), Caudate/Putamen Globus Pallidus (internal), Huntington's Disease ???? lose GABA in caudate putamen, decrease inhibition on GP which increase inhibition on GP so decrease inhibition on thalamus and increase excitation on motor cortex, Basal Ganglia: Dopamine modulating "Fine Tuning" Pathology Huntington's Disease, Caudate/Putament ???? Globus Pallidus (external), Parkinson's Disease ???? DA dies so less excitation of system and greater inhibition of movement, Globus Pallidus (external) Subthalamic nucleus