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This Concept Map, created with IHMC CmapTools, has information related to: G-Protein Coupled Receptors.cmap, G-Protein Coupled Receptors composed of heterotrimeric G protein, subunits: αβγ, GTP to GDP rejoins with βγ complex, Ca+ release from Endoplasmic Reticulum activates CAM Kinase II, GRK (G protein coupled receptor kinase) ???? Arrestin, Protein Kinase A (PKA) phosphorylates receptor, directly blocking GP site, Cyclic AMP (cAMP) ???? Protein Kinase A (PKA), Adenylate Cyclase (AC) ???? Cyclic AMP (cAMP), Ca+ release from Endoplasmic Reticulum activates Protein Kinase C, Phosphorylation at GP intracellular binding site PKA (Protein kinase A), α binds GDP NT binds to transmembrane subunits GDP is repaced by GTP, Phospholipase C (PLC) which activates Inositol triphosphate (IP3), heterotrimeric G protein, subunits: αβγ at resting state α binds GDP, activates α subunit hydrolyzes GTP to GDP, βγ complex reforms heterotrimeric G protein, subunits: αβγ, G-Protein Coupled Receptors deactivated by Phosphorylation, GDP is repaced by GTP which activates α subunit, Diacylglycerol (DAG) activates Protein Kinase C, activates α subunit which activates Phospholipase C (PLC), GTP to GDP potentiated by RGS (regulator of G protein signalling), Phospholipase C (PLC) which activates Diacylglycerol (DAG)