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This Concept Map, created with IHMC CmapTools, has information related to: Cell Mediated, Non Specific Cells Non lymphoid cell types all these cells are capable of releasing lytic enzymes, perforins, TNF and or granzymes when their Fc receptors bind to antibody on the target cell., Non Specific Cells Non lymphoid cell types Eosinophils, Antigen Specific Cells CD8 cytotxoic T lymphocytes (CTL'S) generated by activation of Tcytotoxic cells, Recognize cells coated with antibody (opsonized – Fab attached to antigen, Fc sticking out) ???? can recognize cells that lack MHC molecules, Non Specific Cells Non lymphoid cell types monocytes, Non Specific Cells Non lymphoid cell types macrophages, Non Specific Cells Non lymphoid cell types neutrophils, Non Specific Cells NK Cells Recognize cells coated with antibody (opsonized – Fab attached to antigen, Fc sticking out), Antigen Specific Cells Cytokine Secreting CD4+Th Cells mediates delayed- type hypersensitivity reactions, 3. Dissociation: after granules are released, the cell adhesion starts to loosen ???? 4. Target Cell Destruction, STEPS: Following Activation: 1. conjugation – binding of TCR-CD3-CD8/Class I MHC ???? 3. Dissociation: after granules are released, the cell adhesion starts to loosen, They are CD8+ therefore they are Class I MHC RESTRICTED Phase 1: activation and differentiation STEPS: Following Activation: 1. conjugation – binding of TCR-CD3-CD8/Class I MHC, STEPS: Following Activation: 1. conjugation – binding of TCR-CD3-CD8/Class I MHC 2. Release of FasL when CTL's lack granzymes and perforin they are still able to trigger apoptosis through Fas system, They are CD8+ therefore they are Class I MHC RESTRICTED Phase 1: activation and differentiation Phase 2: Recongnition antigen and engage with target, Non Specific Cells NK Cells IFN alpha and beta and IL-12 activate NK cells., STEPS: Following Activation: 1. conjugation – binding of TCR-CD3-CD8/Class I MHC 2. Release of perforins create holes in target cell membrane, generated by activation of Tcytotoxic cells have lyhtic capability and are critical in the recognition and elimination of altered self cells (virus infected and tumor cells) They are CD8+ therefore they are Class I MHC RESTRICTED, STEPS: Following Activation: 1. conjugation – binding of TCR-CD3-CD8/Class I MHC 2. Release of granules activation of apoptotic pathway