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This Concept Map, created with IHMC CmapTools, has information related to: pathology of esophagus, CMV only strikes in immunocompromised hosts, gastroesophageal reflux disease if long-standing, can lead to Barrett esophagus (in 5-15% of populatns w/ and w/o GERD), esophagitis types gastroesophageal reflux disease, adenocarcinoma clinical features insidious onset dysphagia wt loss anorexia fatigue weakness odynophagia, class 1, dbl stranded DNA viruses ???? CMV, Barrett esophagus (in 5-15% of populatns w/ and w/o GERD) complications need survelliance for: dysplasia, Barrett esophagus (in 5-15% of populatns w/ and w/o GERD) complications adenocarcinoma, Barrett esophagus (in 5-15% of populatns w/ and w/o GERD) chief clinical significance risk for development of adenocarcinoma, squamous cell carcinoma clinical features insidious onset dysphagia wt loss anorexia fatigue weakness odynophagia, CMV Dx endoscopy: biopsy, brushing, achalasia primary loss of innervation, Barrett esophagus (in 5-15% of populatns w/ and w/o GERD) histologic change in distal esophagus, squamos mucosa replaced by intestinal-type columnar epithelial and goblet cells (stains blue w/ Alcian blue at pH 2.5) above gastro- esophageal junction, gastroesophageal reflux disease dominant symptom heartburn, gastroesophageal reflux disease 3 histologic features. only 1-2 may be present eosinophils +- neutrophils in epithelial layer, gastroesophageal reflux disease if long-standing, can lead to bleeding, stricture, infectious types CMV, Candida albicans esophagitis appearance budding yeast forms, pseudohyphae, endoscopy: biopsy, brushing appearance aphthous lesions, or like reflux or Candida esophagitis, infectious types Herpes simplex, adenocarcinoma genetic associations progressive p53 mutations HER-2/NEU and beta-catenin