WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Thalassemia, Beta-thalassemia diagnosed by Hb electrophoresis (High HbA2, HbF), Splicing mutations results in Loss of function of beta-subunit, extramedullary hematopoiesis causes Splenomegaly, β+ - Thalassemia Thalassemia minor causes Excess Alpha globin precipitation, apoptosis leads to Innefective erythropoesis, Inclusions leads to Hypochromic Microcytic RBCs, Shared treatment Plan including Iron chelation, Increased oxygen affinity causes Tissue hypoxia, Shared treatment Plan including Transfusion, Fetal hypoxemia/Death due to Gamma globin tetramers (Hb Barts), β-Thalassemia major or β0 - Thalassemia or Cooley's anemia causes Excess Alpha globin precipitation, Innefective erythropoesis leads to Anemia, African population as One gene deletion per chromosome, Inclusions leads to apoptosis, Folate to Support Increased Hematopoeisis, Iron chelation to Avoid consequences of iron overload, The percentage of affected RBCs is high so Increasing production does not solve anemia, Exccess absorption of dietary iron leads to Secondary Hemochromotosis, Decreased expression of normal beta-subunit classified as β+ - Thalassemia Thalassemia minor, Hemoglobin H disease results in Splenomegaly