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This Concept Map, created with IHMC CmapTools, has information related to: Iron Homeostasis Pathologies, Transferrin receptor mRNA prevents mRNA degredation, Heme kinase which phosphorylates Initiation Factor elF2, Iron concentration causes mRNA binding with low iron concentration, Dietary ferrous iron Fe2+ enters Absorptive enterocytes, Ferritin mRNA encodes Ferritin complexes, Secondary Hemochromatosis as in Transfusions, Excess transfusions causes Increased iron absorption, Ferroportin oxidized by Ceruloplasmin, Ferritin mRNA inhibits ferritin production, Mitoferrin enters Mitochondria, hemolysis can be Extravascular, Heme binds Heme kinase, Increased requirement as in Chronic bleeding, Plummer Vinson syndrome which includes Angular chelitis, endocytosis of membrane channel resulting in Down-regulation of enteral iron absorption, Macrophages via Ferroportin, Plummer Vinson syndrome which includes Atrophic glossitis, Heme transporter exits via Ferroportin, Lead as in Lead Poisining, Iron Responsive Element of Transferrin receptor mRNA