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This Concept Map, created with IHMC CmapTools, has information related to: Sickle Cell, Persistance of fetal Hb induced by Hydroxyurea, Sickle Cell Disease caused by single missense mutation substituting valine in the place of glutamic acid, Splenomegaly leads to Destruction of spleen, Sickle cell trait which provides Defense against malaria, Long transit times through vascular beds as in Inflammed tissue, Polymerization of HbS in T state into long fibers in RBCs (2 alpha globins, 2 beta globins) under conditions of Low oxygen concentration, Homozygous which gives Sickle cell disease, Polymerization of HbS in T state into long fibers in RBCs (2 alpha globins, 2 beta globins) under conditions of Intracellular dehydration, Increased destruction of sickled RBCs causing Splenomegaly, Heterozygous which gives Sickle cell trait, single missense mutation substituting valine in the place of glutamic acid which creates A hydrophobic knob in the beta 2 subunit that fits a hydrophobic pocket on the beta 1 subunit, RBCs sticking to vascular endothelium and clogging capillaries leads to Vascular obstruction, A hydrophobic knob in the beta 2 subunit that fits a hydrophobic pocket on the beta 1 subunit termed HbS (Hemoglobin Sickle cell mutatation), Sickle shape as RBCs pass through conditions of low oxygen tension as in capillaries resulting in RBCs sticking to vascular endothelium and clogging capillaries, single missense mutation substituting valine in the place of glutamic acid inherited through Autosomal recessive pattern, Long transit times through vascular beds as in Spleen, single missense mutation substituting valine in the place of glutamic acid which can be Homozygous, Polymerization of HbS in T state into long fibers in RBCs (2 alpha globins, 2 beta globins) which results in Decreased flexibility of hemoglobin in erythrocytes, A hydrophobic knob in the beta 2 subunit that fits a hydrophobic pocket on the beta 1 subunit which can lead to Polymerization of HbS in T state into long fibers in RBCs (2 alpha globins, 2 beta globins), Vascular obstruction causing Pain