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This Concept Map, created with IHMC CmapTools, has information related to: Retinoblastoma, retinoblastoma gene (RB1) encodes pRb, Loss-of-function results in Unregulated procession to S phase in cell cycle, Unregulated procession to S phase in cell cycle leads to Uncontrolled mitosis, Loss-of-function results in Predisposition for other cancers, Every cell leads to Frequent, Multifocal, Bilateral Tumors, Double hit of mutation to form tumor which explains Incomplete penetrance of disease, Genetic mutation of retinoblastoma gene (RB1), Retinoblastoma caused by Genetic mutation, pRb mutation causes Loss-of-function, Only cells which originated from affected somatic cell leads to Infrequent, Unifocal, Unilateral Tumors, E2F inhibits procession of cells from G1 to S phase, Uncontrolled mitosis results in Tumor formation in eye, retinoblastoma gene (RB1) can be Inherited, procession of cells from G1 to S phase results in Regulation of cell division, Predisposition for other cancers including Bone cancers of the orbit, procession of cells from G1 to S phase results in Tumor suppression, Inherited carries mutation in Every cell, Somatic has mutation in Only cells which originated from affected somatic cell, phosphorylated binds and innactivates E2F, retinoblastoma gene (RB1) requires Double hit of mutation to form tumor