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This Concept Map, created with IHMC CmapTools, has information related to: Immune Response - Adaptive, CD4 TCR bind MHC2 cytokines TGF-β (inhib Tcell, Bcell Δ IgA), clonal expansion differentiation Memory CD4 TCell, 2nd Signal cytokines increase LFA-1 affinity to APC's ICAM-1 . CD8 TCR bind MH1, clonal expansion proliferation & differentiation Plasma cell (lymphoid or bone marrow), CD4 TCR bind MHC2 cytokines INF-γ (macroph activation) IgG, CD4 TCR bind MHC2 cytokines IL-4 (B-Cell Δ IgE), Adaptive Response T Cell CD8 TCR bind MH1, IL-2 CD4 Proliferation clonal expansion, IgG complement act. phagocytes neonatal immun. opsinizing, neutralizing feedback inhib of Bcell Activation, IL-2 CD4 Proliferation clonal expansion, IgE parasite immunity Mast Cell Degranulation, IL-2 CD8 Proliferaiton Kill Infected, IgA mucosal immunity Secretions, CD8 TCR bind MH1 cytokines INF-γ (macroph activation) IgG, CD4 TCR bind MHC2 cytokines IL-5 (eosinophil activation), Differentiation . IgM, IgM classical complement activation ., CD8 TCR bind MH1 cytokines IL-2, 2nd Signal cytokines increase LFA-1 affinity to APC's ICAM-1 . CD4 TCR bind MHC2, B-Cells (naive express IgM & IgD) activation w/ Antigen clonal expansion