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This Concept Map, created with IHMC CmapTools, has information related to: Inflammation, ↑venul perm (swelling, pain) Exudate proteins & cells ↑sg & ↑protein catarrhal, Adherence of Leukocytes diapedesis/ transmigration chemotaxis (C5a, LeukotrieneB4, PAF IL8, MP1, Becterial peptides), Acute Inflamation damaged tissues release TNFα IL-1, chemotaxis (C5a, LeukotrieneB4, PAF IL8, MP1, Becterial peptides) phagocytosis (opsonizing w/ C3b or IgG) Macrophages, ↑venul perm (swelling, pain) Exudate proteins & cells ↑sg & ↑protein Sanguinous, ↑venul perm (swelling, pain) Exudate proteins & cells ↑sg & ↑protein suppurative, PMNs MPO-halide ROS respiratory burst, WBC's marginate TNFα IL-1 ↑ integrin ligands on leukocytes, Macrophages lactoferrin, NO lysozymes, ROS uncontrolled NO can induce shock, C5a, C3a IL1, IL8 cause histamine release from basophils, mast cells, platelets, leukocyte clustering of integrins (high affinity) LFA-1, MAC1 VLA4 Adherence of Leukocytes, ↑ integrin ligands on leukocytes ↑ICAM & VCAM Adherence of Leukocytes, Acute Inflamation 5 Cardinal Signs Redness & Heat, ↑Vasodilation (red, heat) hyperemia ????, chemotaxis (C5a, LeukotrieneB4, PAF IL8, MP1, Becterial peptides) phagocytosis (opsonizing w/ C3b or IgG) PMNs, ↑venul perm (swelling, pain) Exudate proteins & cells ↑sg & ↑protein serous, ↑P & E selectin bind Sialylated Lewis X WBC's marginate, Acute Inflamation Lab Evidence ↑erythrocyte sediment rate (↑ESR), WBC's marginate chemokines leukocyte clustering of integrins (high affinity), Acute Inflamation triple Response Red line, flare pale wheal