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This Concept Map, created with IHMC CmapTools, has information related to: Immune Response - Adaptive - TCells, ↑CD40L on Differentiated TCells binds w/ CD40 ↑B7 on APC's ↑IL12 CD28 on TCell binds B7 on APC, high affinity LFA-1 Adhesion CD28 on TCell binds B7 on APC, Effector CD4 T Cell express CD40Ligand lose CCR7 & L-selectin express E/P selectins VLA binds to VCAM, IL12 (Macrophages, dendritic) promote TH1, Adaptive Response T Cell Mature, Naive express L selectin & CCR7 (helps HEV adhesion) CD8 TCR bind MH1, IL-2 autocrine CD8 Activation & Proliferaiton Effector CTLs (perforin & granzymes) and Fas ligand - apoptosis induction, CD4 TCR bind MHC2 cytokines IL-2 autocrine, IL-2 autocrine CD4 Activation & Proliferation clonal expansion, cytokines . high affinity LFA-1, Memory CD4 TCell . require IL7, CD4 TCR bind MHC2 LFA-1 integrin on Tcell binds w/ ICAM-1 high affinity LFA-1, CD8 TCR bind MH1 cytokines IL-2 autocrine, Effector CD4 T Cell express CD40Ligand migrate to infection TH1, clonal expansion differentiation Effector CD4 T Cell express CD40Ligand, IL4, B7 promote TH2, IL-2 autocrine CD4 Activation & Proliferation ↑CD40L on Differentiated TCells binds w/ CD40, express E/P selectins VLA binds to VCAM migrate to infection Treg, clonal expansion differentiation Memory CD4 TCell, Effector CD4 T Cell express CD40Ligand migrate to infection TH2, TH2 important asthma & Allergies