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This Concept Map, created with IHMC CmapTools, has information related to: Bacteriology 4 gram positive bacilli, diptheria exotoxin (binary) not reqd for survival cause diptheria, virulence factors diff types exotoxins secreted true toxins, Gram+ bacilli aerobes Erysipelothrix rhusiopathiae, diptheria treatment antibiotics erythromycin pen G immunization, exotoxins secreted true toxins diff types small molecule toxins peptides, diptheria exotoxin (binary) not reqd for survival mech inhibits protein synth one molecule can kill one cell, superantigens activate imm sys independent of Ag's e.g. TSS protein assd w/ Stap., virulence factors diff types adhesins: allow attachment to epithelium (e.g. strep/stap -> endocarditis), listeriosis: clinical manisfestation are host-dependent neonates late onset (ɱd after birth) trans-vagnl infx meningoencephalitis, diptheria clinical features CDC reportable 2-5d incubation involves any muc. memb classification based on infx site ant. nasal tonsillar, pharyngeal cutaneous ocular genital can be fatal via organ necrosis, resp insuff., partial paralysis, virulence factors diff types endotoxins, Gram+ bacilli anaerobes clinically imp anaerobes, binary toxins char expressed in many species extrachromosomal encoding not perm part of genome, virulence factors diff types exoenzymes secreted to break down &feed, diptheria doesn't provide protective immunity because toxin conc too low to build imm/Ab response, Gram+ bacilli aerobes Listeria monocytogenes, listeriosis: clinical manisfestation are host-dependent elderly sepsis and meningitis, imm sys avoidance e.g. capsule Ig binding protein imm sys mimics/decoys of host cytokines, diptheria doesn't provide protective immunity toxoid vaccine developed from toxin dev. in 1920's imm should be started during convalescence is formaldehyde-fixed DT, lysins enzymes that cause lysis e.g. listeriolysin