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This Concept Map, created with IHMC CmapTools, has information related to: chemical mediators of inflammation, C3a, C5a mediates chemotaxis, NO destroy tissue, IgG promote opsonization, leukotriene B4 mediates chemotaxis, prostacyclin inhibits platelet aggregation, arachidonic acid ETE, eicosatetraenoic acid lipo-oxygenase pathway (LT's) leukotriene B4, arachidonic acid ETE, eicosatetraenoic acid cyclo-oxygenase pathway prostacyclin, aspirin inhibits cyclo-oxygenase pathway PG, substance P elicit pain (dolor), just like PGE2, PG are vascular dilators (rubor), thromboxane A2 promotes platelet aggregation, lysosomal enzymes from leukocytes destroy tissue, leukotrienes C, D, and E increase incr vascular permeability (tumor), C4a increase incr vascular permeability (tumor), histamine are smooth muscle contractor, aspirin inhibits cyclo-oxygenase pathway prostacyclin, NO inhibits platelet aggregation, IL-6 induces fever, TNF initiates display of P-, E- selectins, IL-1 induces fever