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This Concept Map, created with IHMC CmapTools, has information related to: FLN29, FLN29 links to details of FLN29, FLN29 contains at N terminal end, conserved TRAF-6 binding motif binds to TRAF6, FLN29 contains at middle portion of the protein, middle portion of the protein a conserved TRAF-6 binding motif, TLR4-TRAF6 signalling pathway in macrophages 1 TLR4, TLR4-TRAF6 signalling pathway in macrophages 2 TRAF6, Pro-inflammatory cytokines 2 IL-6, FLN29 KO mice upon LPS stimulation secrete, Pro-inflammatory cytokines 3 IL12p70, TRAF6 causing inhibition of MAPK, secrete more Pro-inflammatory cytokines, Pro-inflammatory cytokines 1 TNF-alpha, TLR4 causing inhibition of NFKB, TRAF6 causing inhibition of NFKB, FLN29 negatively regulates TLR4-TRAF6 signalling pathway in macrophages, TLR4 causing inhibition of MAPK, N terminal end a TRAF-type zinc finger domain, NFKB activation ????, MAPK activation ????