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This Concept Map, created with IHMC CmapTools, has information related to: V27. Thalassemia, 0 leads to Death, Beta Chain relative to The other chain, Unbalanced accumulation of subunits note Severity linked to degree of unbalance, 27. THALASSEMIA arises from Inadequate Hb production, 2 called Alpha trait, Alpha Chain relative to The other chain, Beta Chain called Beta Thalassemia, Beta Major ie. 2 Genes bad, Alpha trait has 25% risk (depending on type), HbH teatment Avoidance of iron, Depend on # functional alpha genes ie 1, 27. THALASSEMIA etiology Non caucasians, Beta thal trait ie 1 Gene bad, Inadequate Hb production causes Microcytosis, Alpha Chain affects .01% to 49%, Inadequate Hb production causes Hypochromia (Iron problems), HbH teatment Folate supplementation, Beta Major have Bad erythropoiesis, Unbalanced accumulation of subunits causes Hemolytic Anemia, Beta Major have Bone Marrow expansion