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This Concept Map, created with IHMC CmapTools, has information related to: V05. CML, Accelerated Phase becomes Blast Crisis (accute leukemia), Accelerated Phase pick up Other chromosome anomalies, Hemopoietic Stem cells which can Become Aggressive, 5. CHRONIC MYLOGENOUS LEUKEMIA type Somatic Mutation, 5. CHRONIC MYLOGENOUS LEUKEMIA Etiology Clonal Expansion, Bcr-Abl located in Cytoplasm, Abelson proto oncogene (ABL) join head to tail on Chromosome 22, 5. CHRONIC MYLOGENOUS LEUKEMIA pathology Breakpoint Cluster Region Gene (BCR), Bone Marrow Transplant unfortunately Patients must be carefully monitored, Clonal Expansion of Hematopoietic Progenitor Cells, Gleevec (Imatinib Mesylate) can help during Blast Crisis (accute leukemia), Breakpoint Cluster Region Gene (BCR) join head to tail on Chromosome 22, Blast Crisis (accute leukemia) blasts can be Lymphoid, 5. CHRONIC MYLOGENOUS LEUKEMIA pathology Abelson proto oncogene (ABL), Bcr-Abl which cause Cell transformation, Initial stage chronic becomes Accelerated Phase, Hemopoietic Stem cells which can Take on other mutations, Bone Marrow Transplant unfortunately Depends on tons of factors, Initial stage chronic development of Malaise, Abelson proto oncogene (ABL) resides on 9q34