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This Concept Map, created with IHMC CmapTools, has information related to: 17. Gluconeogenesis, Not all glycolysis enz work in reverse namely Hexokinase, Glucose 6 Phosphate dephosphorylated to Glucose, Glucose 6 Phosphate dephosphorylated to Note: ATP is not produced during these phosphorylations (Not enough energy), More costly ie 6 NTP's versus 4 for glycolysis, Lactate in liver Can be oxidized, 1,3 BPG which is reduced & dephosphorylated to Note: ATP is not produced during these phosphorylations (Not enough energy), Enz: F1,6 Bisphosphatase dephosphorylated & converted to Glucose 6 Phosphate, GLUCONEOGENESIS substrates Pyruvate, Alanine thus As a pyruvate equivelant, inhibits PK, F1,6BP dephosphorylated & converted to Glucose 6 Phosphate, NADH is required which is reduced & dephosphorylated to Note: ATP is not produced during these phosphorylations (Not enough energy), TCA Intermediates all must pass through Oxaloacetate (OAA), Enz: Pyruvate Carboxylase (PC) rxn considered Anaplerotic, NADH is required which is reduced & dephosphorylated to GA3P, GLUCONEOGENESIS substrates AA's, GLUCONEOGENESIS conceptually Opposite of Anaerobic glycolysis, Enz: Pyruvate Carboxylase (PC) enz requires Biotin, Not all glycolysis enz work in reverse namely PK, Enz: Pyruvate Carboxylase (PC) enz requires CO2, Can be oxidized ie 'Cori' cycle