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This Concept Map, created with IHMC CmapTools, has information related to: Sections 8-10 SKM, Tumor Supressor Genes have various mechanisms of Function, Maintenance Methylation occurs on CpGs, Neurofibromatosis Type 1 features development of Abnormalities, NF1 Gene produces Neurofibromin, NF1 Gene causes Neurofibromatosis Type 1, CpGs occur in high density sites called CpG Islands, DNA Methylation inactivates Tumor Supressor Genes, Abnormalities eg Lisch Nodules, Neurofibrosarcomas can put patients at risk for Glioblastomas, NF1 Gene behaves similarly to Ra Gene, DNA Methylation eg de novo Methylases, Ras Signaling is discussed in Section 5.9, p53 Gene aka TP53, DNA Methylation eg Maintenance Methylation, NF1 Protein present in half- concentration is an example of Haploinsufficiency, Promoter Methylation is a mechanism for Inactivation, CpG Islands are found in Tumors, GTPase-Activating Proteins (GAPs) eg Ras GAP, Neurofibromatosis Type 1 features development of Benign Tumors, DNA Methylation eg Promoter Methylation