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This Concept Map, created with IHMC CmapTools, has information related to: Cmap 2 - ECM proteins, cells attach to the ECM through integrins, fibronectin binds to collagen, cells can use ECM to modulate cellular signalling, fibronectin is zipped up by disulfide bonds, collagen type I is an example of fibrillar collagen, perlecan attach to hyaluronan, elastin is made up of subunits of fibrillin 1 & 2, elastin is an example of one of the extracellular matrix proteins, tropoelastin are capped by galactosugars, actin is a major cytoskeletal filament in cells, actin provides force that changes the conformation of integrins, laminin is an example of one of the extracellular matrix proteins, collagen is broken down by MMP-1, proteoglycans can activate or sequester growth factors, glucosaminoglycan are highly polar, vitronectin is involved in the clotting process, tropoelastin is produced in the endoplasmic reticulum, hyaluronan is an example of a part of the ECM called proteoglycans, gelatin is denatured collagen, extracellular matrix proteins aid in cellular signalling