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This Concept Map, created with IHMC CmapTools, has information related to: Gaucher Disease, 81% reduction in WBC beta glucosidase activity characterized by deficiency in glucocerebrosidase, BBB results in ineffective treatment of Chronic Neuropathic (Type III), normal hematopoietic cells leads to anemia, thrombocytopenia causes repeated bruising, Ceredase cannot cross BBB, BBB results in ineffective treatment of Acute Neuropathic (Type II), macrophages with accumulation of glucocerebrosides can rupture to release lysosomal enzymes and acid, platelets leading to thrombocytopenia, to release lysosomal enzymes and acid weakens long bone causing susceptibility to bone fractures, thrombocytopenia causes frequent nosebleeds, macrophages with accumulation of glucocerebrosides causes disruption in vascular flow, bone marrow produces reduced numbers of platelets, hepatosplenomegaly becomes overactive, breaking down red blood cells, 2 distinct mutations mutations include N370S, 2 distinct mutations mutations include IVS2+1G to A, erythrocytopenia causes anemia, red blood cells causing erythrocytopenia, disruption in vascular flow which increases risk of ischemia, hepatosplenomegaly becomes overactive, breaking down platelets, ischemia weakens long bone causing susceptibility to bone fractures