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This Concept Map, created with IHMC CmapTools, has information related to: LDL receptor defRLedits_2012 (1).cmap, de novo free cholesterol contributing towards 1150mg/dL cholesterol at age 3, TG hydrolization creating glycerol, coronary artery causes ischemia, cleavage of complex releasing SREBP, Family History which includes cholesterol levels (300-400mg/dL), LDL are coated with ApoB100, low free intracellular cholesterol (FIC) reduces activity of ACAT, lipoprotein lipase on endothelial cells which caused TG hydrolization, class 1 or class 2A mutation suggests autosomal codominant, clinical diagnosis of homozygous familial hypercholesterolemia could be treated with low fat/cholesterol diet with statin, IDL returns Apo CII and Apo E to HDL, bile acid sequestrants bind and prevent the recycling of (promote excretion of) bile acids, 10 year old girl is found to have tendonous and cutaneous xanthomas, class 1 or class 2A mutation presents as clinical diagnosis of homozygous familial hypercholesterolemia, parents with heterzygous FH genotype each possess one class 1 or class 2A mutation, normal triglyceride levels leads to clinical diagnosis of homozygous familial hypercholesterolemia, low free intracellular cholesterol (FIC) increases HMG CoA reductase, Atherosclerotic plaque characterizes premature coronary artery disease, bile production by activity of 7-alpha hydroxlase, bile production which enters the enterohepatic circulation